Human exposure assessment in the framework of European chemicals control legislation REACH: from industrial hygiene to exposure science


  • Ian Urbanus Belgian Shell NV; Kantersteen 47; B-1000 Brussel/Bruxelles



REACH, DNEL, exposure scenarios


The European chemicals control regulation REACH requires quantitative assessment to demonstrate that worker inhalation and dermal exposure levels remain below toxicological reference values (Derived No Effect Levels) during the entire life cycle of a chemical. This has stimulated the development of a new and efficient approach that allows focus on potentially problematic chemical applications, whilst providing reasonable assurance that exposure in less challenging conditions is of no concern. The approach was necessary to deal with a very large number of exposure scenarios in a comparatively short time-frame and emerged from a process of simplification and standardization building on industrial hygiene knowledge of worker exposure determinants and good practice recommendations for exposure control.


Regulation (EC) No 1907/2006 of the European Parliament and of the Council of 18 December 2006 concerning the Registration, Evaluation, Authorisation and Restriction of Chemicals (REACH), establishing a European Chemicals Agency, amending Directive 1999/45/EC and repealing Council Regulation (EEC) No 793/93 and Commission Regulation (EC) No 1488/94 as well as Council Directive 76/769/EEC and Commission Directives 91/155/EEC, 93/67/EEC, 93/105/EC and 2000/21/EC

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