Assessment of an Occupational Risk Factor for Metabolic Syndrome
Keywords:Metabolic Syndrome, Chemical Hazards, Solvents
Over the last decades, there has been a significant increase in metabolic syndrome (MS), related to the global obesity epidemic. Among the associated factors, it should be noted that occupational exposure to chemicals is a possible etiology in the development of metabolic syndrome. Thus, the treatment usually proposed for MS, with diet and physical activity, may have limited effectiveness in workers exposed to chemical products. The objective of this study was to compare the risk factors for MS between a sample of workers occupationally exposed to organic solvents and a sample of unexposed workers. A cross-sectional study consisting of 99 male workers was conducted, including 53 workers exposed to chemical hazards in the workday and 46 workers without evidence of exposure. The first group was selected among workers that are exposed to organic solvents during their workday and the second group was selected randomly in a hospital, with no evidence of chemical exposure. A positive association was found between increased triglyceride levels and exposure to chemical hazards (37.3% for the exposed group vs. 21.7% for the unexposed group). An association between duration of exposure and hypertriglyceridemia (p<0.001) was found as well. Excluding age as a confounding variable, it was noted that the exposed group had higher triglyceride levels and that a longer exposure was proportional to this increase, which suggests a possible association between exposure to chemical products and MS.
Alberti, K.G.; Zimmet, P.Z. Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med. 1998; 15(7): 539-53.
Bloomgarden, Z.T. American Association of Clinical Endocrinologists (AACE) consensus conference on the insulin resistance syndrome: 25-26 August 2002, Washington, DC. Diabetes Care. 2003; 26(4): 1297-303.
Brautbar N, Williams J. Industrial solvents and liver toxicity: risk assessment, risk factors and mechanisms. International Journal of Hygiene and environmental. Health 2002; (205): 479-491.
Cleeman, J.I.; et al. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults Cotrim, H.P., et al. Nonal (Adult Treatment Panel III). JAMA. 2001; 285(19): 2486-97.
Cotrim, H.P.; et al. Nonalcoholic steatohepatitis: a toxic liver disease in industrial workers. Liver. 1999; 19(4): 299-304. Eckel, R.H.; Grundy, S.M.; Zimmet, P.Z. The metabolic Syndrome. Lancet. 2005; 365(9468): 1415-28.
Daskalopoulou SS, Athyros VG, Kolovou GD, Anagnostopoulou KK, Mikhailidis DP. Definitions of metabolic syndrome: Where are we now? Curr Vasc Pharmacol. 2006 Jul;4(3):185-97
Eckel, R.H.; Grundy,S.M.;Zimmet, P.Z. The metabolic Syndrome, Lancet, 2005; 365(9468): 1415-28.
Friedewald, W.; Levy, R.; Fredckson, D. Estimation of low-density Lipoprotein Cholesterol in Plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972; 18: 499-502.
Grundy, S.M.; et al. American Heart Association; National Heart, Lung, and Blood Institute. Definition of metabolic syndrome: report of the National Heart, Lung, and Blood Institute/American Heart Association Conference on Scientific Issues Related to Definition. Circulation. 2004; 109(3):433-8.
James-Todd, T.M.; et al. The association between phthalates and metabolic syndrome: the National Health and Nutrition Examination Survey 2001 - 2010. Environ Health. 2016; 15:52.
I- Kaukiainen, A; et al. Results of common laboratory tests in solvent-exposed workers. Int Arch Occup Environ Health. 2004; 77:39-46.
II- Kaukiainen, A.; et al. Solvent-related health effects among construction painters with decreasing exposure. Am J Ind Med. 2004; 45: 627-36.
Kim K.W.; Won Y.L.; Ko K.S.; et al. The effects of hazardous chemical exposure on cardiovascular disease in chemical products manufacturing workers. Toxicol Res. 2012; 28: 269â€“277.
Ma X.; Holalkere N.S.; Kambadakone R.A.; et al. Imaging-based Quantification of Hepatic Fat: Methods and Clinical Applications. Radiographics. 2009; 29: 1253-1280.
Monteiro, R.; Azevedo, I. Chronic inflammation in obesity and the metabolic syndrome. Mediators Inflamm. 2010.
Ryan, J.G. Cost and policy implications from the increasing prevalence of obesity and diabetes mellitus. Gend Med. 2009; 6(Suppl 1):86-108.
Salaroli, L.B.; et al. PrevalÃªncia de SÃndrome MetabÃ³lica em Estudo de Base Populacional, VitÃ³ria, ES â€“ Brasil. Arq Bras Endocrinol Metab. 2007; 51(7): 1143-52.
Sirit, Y.; et al. SÃndrome MetabÃ³lico y otros Factores de Riesgo Cardiovascular en Trabajadores de una Planta de Policloruro de Vinilo â€“ Rev Salud PÃºblica. 2008; 10(2): 239-249.
Taino, G.; et al. Metabolic syndrome and shift work: study of the relationship in workers of a chemical plant. G Ital Med Lav Ergon. 2011; 33(4):456-61.
Wahlang, B.; et al. Toxicant-associated steatohepatitis. Toxicologic pathology. 2013; (41): 343-360.
Yamaoka, K.; Tango, T. Effects of lifestyle modification on metabolic syndrome: a systematic review and meta-analysis. BMC Med. 2012; 14;10(1):138.